NADH: The molecule responsible for energy in our body.

NADH is a fundamental molecule in the body’s energy metabolism, acting as a coenzyme in the process of energy production through cellular respiration. Optimizing NADH levels directly translates into improving energy efficiency and overall cellular function.

Normally, our body produces enough NADH for its needs. However, factors such as age, a poor diet, excess sugar, smoking, alcohol consumption, oxidative stress, or intense physical and/or mental activity can reduce its availability.

In these situations, Nergy NADH offers a rapid and effective source. Thanks to its sublingual absorption, it bypasses the intestine, ensuring direct delivery and reducing the risk of losses or digestive intolerance.

It is crucial to note that stabilizing NADH in a supplement requires special protection from environmental agents like oxygen, light, humidity, and, particularly, temperature.

Two decades of experience from GNP Global Nature Products as the producer, and from Nergy.Club s.r.l., as the exclusive distributor in Italy, guarantee a product that maintains a high content of stable NADH.

Scientifically Supported Benefits of NADH

NADH (Reduced Nicotinamide Adenine Dinucleotide) acts as a key cofactor for energy metabolism and cellular health, directly influencing several physiological domains:

1. Optimizing Physical Performance and Endurance

NADH is the direct substrate for Complex I of the Electron Transport Chain (ETC).

  • Increased ATP Production: It maximizes the efficiency of mitochondrial oxidative phosphorylation (OXPHOS), boosting energy yield per unit of oxygen consumed.

  • Reduced Muscle Fatigue: It supports ATP replenishment for the Na+/K+-ATPase pump and PCr resynthesis after exertion, enhancing resistance to fatigue and accelerating muscle recovery.

2. Cognitive Support and Neuroprotection

The brain has the highest metabolic rate of any tissue, making its function highly dependent on NADH.

  • Improved Focus and Alertness: It provides the necessary ATP for the high firing rate of neurons and supports the synthesis of essential neurotransmitters (like dopamine) through the regeneration of cofactors (BH4).

  • Mitigation of Cognitive Fatigue: It helps alleviate the feeling of mental tiredness, supporting executive function under stressful conditions.

3. Management of Oxidative Stress and Cellular Longevity

NADH is vital for maintaining the correct cellular redox balance.

  • Indirect Antioxidant Action: NADH (and its derivative, NADPH) is fundamental for regenerating reduced glutathione (GSH), the body's primary endogenous antioxidant.

  • Reduced Exercise-Induced Damage: It helps decrease oxidative stress generated by intense exercise due to mitochondrial electron leakage, protecting cell membranes and proteins from damage by reactive oxygen species (ROS).

4. Support for the Gut–Brain Axis

  • Barrier Integrity: It supplies essential ATP for maintaining tight junctions and repairing enterocytes, thereby helping to reduce systemic inflammation that can negatively affect brain function.

In summary, NADH acts as a cellular metabolic optimizer, improving the amount of available energy, protecting cellular structures, and supporting complex neurochemical processes.

Scientific Sources:

  1. Cooke, M., et al. (2008). “Effects of on performance of professional cyclists: a double-blind, placebo-controlled trial”. Journal of the International Society of Sports Nutrition, 5, 24.
  2. Sarmiento, A., et al. (2011). “Coenzyme Supplementation and Exercise in Healthy Humans”. Journal of Sports Science and Medicine, 10(4), 661–668.
  3. Yama, E., et al. (2015). “Effect of Supplementation on Markers of Exercise-Induced Muscle Damage and Inflammation”. International Journal of Sports Medicine, 36(13), 1083–1090.
  4. Dollerup, O., et al. (2020). “Role of Nicotinamide Riboside in cellular bioenergetics and its utility in sports nutrition”. Journal of Nutritional Biochemistry, 85, 108465. (Review contestuale che supporta il ruolo del / nello stress ossidativo e nel metabolismo energetico.)
  5. Hagen, R. P., et al. (2015). “Mitochondrial dysfunction and : A review of current research”. Mitochondrion, 24, 69–77. (Review sulla funzione mitocondriale e , contestualmente applicabile al riciclo del lattato e all’efficienza .)
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